PRiming IMmunity At the
beginning of Life
PRIMAL
PRiming IMmunity At the beginning of Life
PRIMAL
Presse
Pressemitteilung vom 05.08.2024
Pressemitteilung vom 30.07.2020
Publikationen
2024
Van Rossum T, Haiß A, Knoll RL, Marißen J, Podlesny D, Pagel J, Bleskina M, Vens M, Fortmann I, Siller B, Ricklefs I, Klopp J, Hilbert K, Meyer C, Thielemann R, Goedicke-Fritz S, Kuntz M, Wieg C, Teig N, Körner T, Kribs A, Hudalla H, Knuf M, Stein A, Gille C, Bagci S, Dohle F, Proquitté H, Olbertz DM, Schmidt E, Koch L, Pirr S, Rupp J, Spiegler J, Kopp MV, Göpel W, Herting E, Forslund SK, Viemann D, Zemlin M, Bork P, Gehring S, König IR, Henneke P, Härtel C
Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants: The PRIMAL Randomized Clinical Trial
JAMA Pediatr. doi:10.1001/jamapediatrics.2024.2626.
https://pubmed.ncbi.nlm.nih.gov/39102225/
2023
Kindt ASD, Förster KM, Cochius-den Otter SCM, Flemmer AW, Hauck SM, Flatley A, Kamphuis J, Karrasch S, Behr J, Franz A, Härtel C, Krumsiek J, Tibboel D, Hilgendorff A
Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia
Pediatr Res. 2023 Feb;93(3):625-632. doi: 10.1038/s41390-022-02093-w. Epub 2022 May 20.
https://pubmed.ncbi.nlm.nih.gov/35595912/
Silwedel C, Hütten MC, Speer CP, Härtel C, Haarmann A, Henrich B, Tijssen MPM, Alnakhli AA, Spiller OB, Schlegel N, Seidenspinner S, Kramer BW, Glaser K.
Ureaplasma-Driven Neonatal Neuroinflammation: Novel Insights from an Ovine Model
Cell Mol Neurobiol. 2023 Mar;43(2):785-795
https://pubmed.ncbi.nlm.nih.gov/35334011/
2022
Hanke K, Rausch TK, Sosnowski R, Paul P, Spiegler J, Müller M, König IR, Göpel W, Herting E, Härtel C.
Early Skin-to-Skin Contact Does Not Affect Cerebral Tissue Oxygenation in Preterm Infants under 32 Weeks of Gestation
Children (Basel). 2022 Feb 6;9(2):211. doi: 10.3390/children9020211.PMID: 35204931
https://doi.org/10.3390/children9020211
Fortmann MI, Dirks J, Goedicke-Fritz S, Liese J, Zemlin M, Morbach H, Härtel C.
Immunization of preterm infants: current evidence and future strategies to individualized approaches
Semin Immunopathol. 2022 Nov;44(6):767-784. doi: 10.1007/s00281-022-00957-1. Epub 2022 Aug 3.PMID: 35922638
https://pubmed.ncbi.nlm.nih.gov/35922638/
Bossung V, Lupatsii M, Dashdorj L, Tassiello O, Jonassen S, Pagel J, Demmert M, Wolf EA, Rody A, Waschina S, Graspeuntner S, Rupp J, Härtel C.
Timing of antimicrobial prophylaxis for cesarean section is critical for gut microbiome development in term born infants
Gut Microbes. 2022 Jan-Dec;14(1):2038855. doi: 10.1080/19490976.2022.2038855.PMID: 35184691
https://doi.org/10.1080/19490976.2022.2038855
Faust KB, Moser K, Bartels M, Fortmann I, Hanke K, Wieg C, Stichtenoth G, Göpel W, Herting E, Härtel C.
Lactoferrin and Human Neutrophil Protein (HNP) 1-3 Levels During the Neonatal Period in Preterm Infants.
Front Pediatr. 2022 Jul 27;10:909176. doi: 10.3389/fped.2022.909176. eCollection 2022.PMID: 35967550
https://pubmed.ncbi.nlm.nih.gov/35967550/
Neitmann J, Hanke K, Humberg A, Siller B, Spiegler J, Juhnke K, Gilmore J, Odendahl R, Herting E, Göpel W, Härtel C, Fortmann I; German Neonatal Network (GNN)
Sleep problems in infancy and early school age in very preterm infants
Early Hum Dev.2022 Oct;173:105656.
https://pubmed.ncbi.nlm.nih.gov/35987047/
Bubser C, Liese J, Serna-Higuita LM, Müller A, Vochem M, Arand J, Karck U, Gross M, Poets CF, Härtel C, Zemlin M, Gille C, Köstlin-Gille N.
Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis
Antimicrob Resist Infect Control. 2022 May 19;11(1):72. doi: 10.1186/s13756-022-01110-1.PMID: 35590392
https://doi.org/10.1186/s13756-022-01110-1
Humberg A, Fortmann MI, Spiegler J, Rausch TK, Siller B, Silwedel C, Marissen J, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN)
Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age
Neonatology. 2022;119(6):695-702
https://doi.org/10.1159/000525709
Kopp MV, Weckmann M, Nissen G, Ricklefs I, Härtel C.
Two Beer(s) or Not Two Beer(s): The eNose as an Instrument to Pacify the World
Klin Padiatr. 2022 Sep;234(5):301-304. doi: 10.1055/a-1714-8895. Epub 2022 Feb 9.PMID: 35139542
https://pubmed.ncbi.nlm.nih.gov/35139542/
Klopp, J, Ferretti, P, Meyer CU, Hilbert K, Haiß A, Marißen J, Henneke P, Hudalla H, Pirr S, Viemann D, Zemlin M, Forslund SK, Härtel C, Boork P, Gehring S, Van Rossum T, PRIMAL Cornsortium
Meconium Microbiome of Very Preterm Infants across Germany
mSphere 2022, 7 (1)
https://doi.org/10.1128/msphere.00808-21
2021
Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B; Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Henneke P
Cytomegalovirus subverts macrophage identity.
Cell. 2021. in press
https://doi.org/10.1016/j.cell.2021.05.009
Freundenhammer M, Karampatsas K, Le Doare K, Lander, F, Armann J, Moreno AD, Boyle M, Buxmann H, Campbel R, Chalker V, Cunney R, DOherty L, Davies E, Efstratiou A, Elling R, Endmann M. Essers J, Hentschel R, Jones CE, Kallsen S, Kapatai G, Krüger M, Ladhani S, Lamagni T, Lindsay D, Meehan M, O’Sulivan CP, Patel D, Reynolds AJ, Roll C, Schulzke S, Smith A, Stein A. von der Wnese A, Voss E, Wieg C, Härtel C, Health PT, Henneke P
Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis.
Front Immunol. 2021 June 21; Article 617925
https://doi.org/10.3389/fimmu.2021.617925
Henneke P, Kierdorf K, Hall L, Sperandio M, Hornef M.
Perinatal development of innate immune topology.
Elife. 2021 May 25;10:e67793.
doi: 10.7554/eLife.67793. PMID: 34032570
Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P.
Monocyte progenitors give rise to multinucleated giant cells.
Nat Commun. 2021 Apr 1;12(1):2027.
doi.org/10.1038/s41467-021-22103-5
2020
Härtel C, Faust K, Fortmann I, Humberg A, Pagel J, Haug C, Kühl R, Bohnhorst B, Pirr S, Viemann D, Simon A, Zemlin M, Poralla S, Müller A, Köstlin-Gille N, Gille C, Heckmann M, Rupp J, Herting E, Göpel W.
Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms.
Antimicrob Resist Infect Control. 2020.26;9(1):144.
doi: 10.1186/s13756-020-00804-8.
Siegmund M, Pagel J, Scholz T, Rupp J,Härtel C, Lauten M.
Pro-inflammatory cytokine ratios determine the clinical course of febrile neutropenia in children receiving chemotherapy.
Mol Cell Pediatr. 2020.9;7(1):5.
doi: 10.1186/s40348-020-00097-2.
Bossung V, Fortmann MI, Fusch C, Rausch T, Herting E, Swoboda I, Rody A,Härtel C, Göpel W, Humberg A.
Neonatal Outcome After Preeclampsia and HELLP Syndrome: A Population-Based Cohort Study in Germany.
Front Pediatr. 2020.12;8:579293.
doi: 10.3389/fped.2020.579293. eCollection 2020.
Herting E, Kribs A,Härtel C, von der Wense A, Weller U, Hoehn T, Vochem M, Möller J, Wieg C, Roth B, Göpel W; German Neonatal Network (GNN).
Share Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study.
Eur J Pediatr. 2020.179(8):1309-1313.
doi: 10.1007/s00431-020-03572-0.
Share S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Gastroenterology. 2020 Aug 15:S0016-5085(20)35058-7.
Resident macrophages acquire innate immune memory in staphylococcal skin infection.
Elife. 2020 Jul 8;9:e55602.
Kuntz M, Kohlfürst DS, Feiterna-Sperling C, Krüger R, Baumann U, Buchtala L, Elling R, Grote V, Hübner J, Hufnagel M, Kaiser-Labusch P, Liese J, Otto E-M, Rose MA, Schneider C, Schuster V, Seidl M, Sommerburg O, Vogel M, von Bernuth H, Weiß M, Zimmermann T, Nieters A, Zenz W, Henneke P, NTMkids Consortium.
Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children
Emerg Infect Dis. 2020. 26(3):579-586
Humberg A, Spiegler J, Fortmann MI, Zemlin M, Marissen J, Swoboda I, Rausch TK, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN).
Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age.
Sci Rep. 2020. 10: 2373.
Fortmann I, Marißen J, Siller B, Spiegler J, Humberg A, Hanke K, Faust K, Pagel J, Eyvazzadeh L, Brenner K, Roll C, Pirr S, Viemann D, Stavropoulou D, Henneke P, Tröger B, Körner T, Stein A, Derouet C, Zemlin M, Wieg C, Rupp J, Herting E, Göpel W, Härtel C.
Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics are beneficial to extremely low gestational age infants fed human milk.
Nutrients. 2020.12:850.
Humberg A, Härtel C, Rausch TK, Stichtenoth G, Jung P, Wieg C, Kribs A, von der Wense A, Weller U, Höhn T, Olbertz DM, Felderhoff-Müser U, Rossi R, Teig N, Heitmann F, Schmidtke S, Bohnhorst B, Vochem M, Segerer H, Möller J, Eichhorn JG, Wintgens J, Böttger R, Hubert M, Dördelmann M, Hillebrand G, Roll C, Jensen R, Zemlin M, Mögel M, Werner C, Schäfer S, Schaible T, Franz A, Heldmann M, Ehlers S, Kannt O, Orlikowsky T, Gerleve H, Schneider K, Haase R, Böckenholt K, Linnemann K, Herting E, Göpel W.
Active perinatal care of preterm infants in the German Neonatal Network.
Arch Dis Child Fetal Neonatal Ed. 2020. 105: 190-195.
Marissen J, Fortmann I, Humberg A, Rausch TK, Simon A, Stein A, Schaible T, Eichhorn J, Wintgens J, Roll C, Heitmann F, Herting E, Göpel W, Härtel C, German Neonatal Network.
Vancomycin-induced ototoxicity in very-low-birthweight infants.
J Antimicrob Chemother. 2020; doi: 10.1093/jac/dkaa156.
Humberg A, Fortmann I, Siller B, Kopp MV, Herting E, Göpel W, Härtel C, German Neonatal Network, German Center for Lung Research and Priming Immunity at the beginning of life (PRIMAL) Consortium.
Preterm birth and sustained inflammation: consequences for the neonate.
Semin Immunopathol. 2020; doi: 101007/s00281-020-00803-2
Astiz M, Heyde I, Fortmann MI, Bossung V, Roll C, Stein A, Grüttner B, Göpel W, Härtel C, Obleser J, Oster H.
The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders.
Nat Commun. 2020. 11:3593.
Kolter J, Kierdorf K, Henneke P.
Origin and Differentiation of Nerve-Associated Macrophages
J Immunol. 2020. 204(2):271-279.
Ammann S, Fuchs S, Martin-Martin L, Castro CN, Spielberger B, Klemann C, Elling R, Heeg M, Speckmann C, Hainmann I, Kaiser-Labusch P, Horneff G, Thalhammer J, Bredius RG, Stadt UZ, Lehmberg K, Fuchs I, von Spee-Mayer C, Henneke P, Ehl S.
Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies
J Allergy Clin Immunol. 2020. 145(1):434-437.e4; doi: 10.1016/j.jaci.2019.09.002.
Tröger B, Heidemann M, Osthues I, Knaack D, Göpel W, Herting E, Knobloch JK, Härtel C.
Modulation of S. epidermidis-induced innate immune responses in neonatal whole blood
J Microbiol Immunol Infect 2020. 53: 240-249
2019
Marißen J, Haiß A, Meyer C, Van Rossum T, Bünte LM, Frommhold D, Gille C, Goedicke-Fritz S, Göpel W, Hudalla H, Pagel J, Pirr S, Siller B, Viemann D, Vens M, König I, Herting E, Zemlin M, Gehring S, Bork P, Henneke P, Härtel C; PRIMAL consortium. 2019.
Efficacy of Bifidobacterium animalis subsp. lactis (BB-12), B. infantis and Lactobacillus acidophilus (La-5) probiotics to prevent gut dysbiosis in preterm infants of 28+0-32+6 weeks of gestation: a randomised, placebo-controlled, double-blind, multicentre trial: the PRIMAL Clinical Study protocol
BMJ Open. 9(11):e032617.
Feuerstein R, Gres V, Perdigo NE, Baasch S, Freudenhammer M, Elling R, Henneke P. 2019.
Macrophages are a potent source of streptococcus-induced interferon-β
J Immunol 19; published online 15 November 2019
Freudenhammer M, Henneke P, Härtel C. 2019.
Mikrobiom von Risikoneugeborenen und präventive Modifikation
Monatsschr Kinderh 19, 167:411–419
Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d’Errico P, Baasch S, Amann L, Masuda T, Lösslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke C, Grün D, Lämmermann T, Prinz M, Henneke P. 2019.
A subset of skin macrophages contributes to surveillance and regeneration of local nerves
Immunity 19; 50(6):1482-1497
Gres V, Kolter J, Erny D, Henneke P. 2019.
The role of CNS macrophages in streptococcal meningoencephalitis
J Leukoc Biol 19; 106(1):209-218
Twisselmann N, Bartsch YC, Pagel J, Wieg C, Hartz A, Ehlers M, Härtel C. 2019.
IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age
Front Immunol 19; 9:3166
2018
Fortmann I, Hartz A, Paul P, Pulzer F, Müller A, Böttger R, Proquitté H, Dawczynski K, Simon A, Rupp J, Herting E, Göpel W, Härtel C; German Neonatal Network. 2018.
Antifungal Treatment and Outcome in Very-Low-Birth-Weight-Infants – A Population-Based Observational Study of the German Neonatal Network
Pediatr Infect Dis J 18; 37: 1165-1171
Graspeuntner S, Waschina S, Künzel S, Twisselmann N, Rausch TK, Cloppenborg-Schmidt K, Zimmermann J, Viemann D, Herting E, Göpel W, Baines JF, Kaleta C, Rupp J, Härtel C, Pagel J. 2018.
Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants
Clin Infect Dis 18; 69(2):268-277
Härtel C, Paul P, Hanke K, Humberg A, Kribs A, Mehler K, Vochem M, Wieg C, Roll C, Herting E, Göpel W. 2018.
Less invasive surfactant administration and complications of preterm birt
Sci Rep 18; 8: 8333
Hartz A, Schreiter L, Pagel J, Moser K, Wieg C, Grotheer A, Rupp J, Herting E, Göpel W, Härtel C. 2018.
Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants
Pediatr Res 18; 84: 134-138
Hudalla H, Karenberg K, Kuon R, Pöschl J, Tschada R, Frommhold D. 2018.
LPS-induced maternal inflammation promotes fetal leukocyte recruitment and prenatal organ infiltration in mice
Pediatr Res 18; 84:757 – 764
Schwarz J, Scheckenbach V, Kugel H, Spring B, Pagel J, Härtel C, Pauluschke-Fröhlich J, Peter A, Poets CF, Gille C, Köstlin N. 2018.
Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period
Clin Exp Immunol 18; 191: 328-337
2017
Härtel C, Pagel J, Spiegler J, Buma J, Henneke P, Zemlin M, Viemann D, Gille C, Gehring S, Frommhold D, Rupp J, Herting E, Göpel W. 2017.
Lactobacillus acidophilus/ Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics
Sci Rep 17; 7:5633
Köstlin N, Vogelmann M, Spring B, Schwarz J, Feucht J, Härtel C, Orlikowsky TW, Poets CF, Gille C. 2017.
Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype
Immunology 17; 152: 89-101
Kolter J, Henneke P. 2017.
Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease
Font Immunol 17; 8:1497
Pirr S, Richter M, Fehlhaber B, Pagel J, Härtel C, Roth J, Vogl T, Viemann D. 2017.
High Amounts of S100-Alarmins Confer Antimicrobial Activity on Human Breast Milk Targeting Pathogens Relevant in Neonatal Sepsis
Front Immunol 17; 8: 1822
Veranstaltungen
13 – 14 July 2017
Kick-off meeting of the PRIMAL Consortium
Frankfurt, Germany
27 – 29 September 2017
Development of tissue and pathogen specific cellular innate immunity. International Symposium
Freiburg, Germany
28 February 2018
Workshop PRIMAL Biosamples and 2nd meeting of the PRIMAL Consortium
Hannover, Germany
20 September 2018
3rd meeting of the PRIMAL Consortium
Lübeck, Germany
3 – 4 April 2019
4th meeting of the PRIMAL Consortium
Freiburg, Germany
7 – 11 June 2020
Immunity in Early Life: From the Maternal to the Microbial Environment
Keystone Resort, Keystone, CO, USA
weitere Informationen:
http://bit.ly/KSimmune20
Media Toolkit:
http://bit.ly/DTKimmune20
2 December 2020
5th meeting of the PRIMAL Consortium
web-meeting
1 – 2 July 2021
6th meeting of the PRIMAL Consortium
Würzburg, Germany
24 – 25 October 2022
7th meeting of the PRIMAL Consortium
Würzburg, Germany