Darmflora

PRiming IMmunity At the
beginning of Life

PRIMAL

Darmflora

PRiming IMmunity At the beginning of Life

PRIMAL

Presse

Pressemitteilung vom 30.07.2020

Publikationen

2021

Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B; Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Henneke P

Cytomegalovirus subverts macrophage identity.

Cell. 2021. in press
https://doi.org/10.1016/j.cell.2021.05.009

Freundenhammer M, Karampatsas K, Le Doare K, Lander, F, Armann J, Moreno AD, Boyle M, Buxmann H, Campbel R, Chalker V, Cunney R, DOherty L, Davies E, Efstratiou A, Elling R, Endmann M. Essers J, Hentschel R, Jones CE, Kallsen S, Kapatai G, Krüger M, Ladhani S, Lamagni T, Lindsay D, Meehan M, O’Sulivan CP, Patel D, Reynolds AJ, Roll C, Schulzke S, Smith A, Stein A. von der Wnese A, Voss E, Wieg C, Härtel C, Health PT, Henneke P

Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis.

Front Immunol. 2021 June 21; Article 617925
https://doi.org/10.3389/fimmu.2021.617925

Henneke P, Kierdorf K, Hall L, Sperandio M, Hornef M.

Perinatal development of innate immune topology.

Elife. 2021 May 25;10:e67793.
doi: 10.7554/eLife.67793. PMID: 34032570

Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P.

Monocyte progenitors give rise to multinucleated giant cells.

Nat Commun. 2021 Apr 1;12(1):2027.
doi.org/10.1038/s41467-021-22103-5

2020

Härtel C, Faust K, Fortmann I, Humberg A, Pagel J, Haug C, Kühl R, Bohnhorst B, Pirr S, Viemann D, Simon A, Zemlin M, Poralla S, Müller A, Köstlin-Gille N, Gille C, Heckmann M, Rupp J, Herting E, Göpel W.

Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms.

Antimicrob Resist Infect Control. 2020.26;9(1):144.
doi: 10.1186/s13756-020-00804-8.

Siegmund M, Pagel J, Scholz T, Rupp J,Härtel C, Lauten M.

Pro-inflammatory cytokine ratios determine the clinical course of febrile neutropenia in children receiving chemotherapy.

Mol Cell Pediatr. 2020.9;7(1):5.
doi: 10.1186/s40348-020-00097-2.

 

Bossung V, Fortmann MI, Fusch C, Rausch T, Herting E, Swoboda I, Rody A,Härtel C, Göpel W, Humberg A.

Neonatal Outcome After Preeclampsia and HELLP Syndrome: A Population-Based Cohort Study in Germany.

Front Pediatr. 2020.12;8:579293.
doi: 10.3389/fped.2020.579293. eCollection 2020.

 

Herting E, Kribs A,Härtel C, von der Wense A, Weller U, Hoehn T, Vochem M, Möller J, Wieg C, Roth B, Göpel W; German Neonatal Network (GNN).

Share Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study.

Eur J Pediatr. 2020.179(8):1309-1313.
doi: 10.1007/s00431-020-03572-0.

 

Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF,Härtel C, Schultze JL, Forslund SK, Roth J, Viemann D.

Share S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.

Gastroenterology. 2020 Aug 15:S0016-5085(20)35058-7.

Feuerstein R, Forde AJ, Lohrmann F, Kolter J, Ramirez NJ, Zimmermann J, Gomez de Agüero M, Henneke P. 

Resident macrophages acquire innate immune memory in staphylococcal skin infection.

Elife. 2020 Jul 8;9:e55602.

 

Kuntz M, Kohlfürst DS, Feiterna-Sperling C, Krüger R, Baumann U, Buchtala L, Elling R, Grote V, Hübner J, Hufnagel M, Kaiser-Labusch P, Liese J,  Otto E-M, Rose MA, Schneider C,  Schuster V, Seidl M, Sommerburg O, Vogel M, von Bernuth H, Weiß M, Zimmermann T, Nieters A, Zenz W, Henneke P, NTMkids Consortium. 

Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

Emerg Infect Dis. 2020. 26(3):579-586

 

Humberg A, Spiegler J, Fortmann MI, Zemlin M, Marissen J, Swoboda I, Rausch TK, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN).

Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age.

Sci Rep. 2020. 10: 2373.

 

Fortmann I, Marißen J, Siller B, Spiegler J, Humberg A, Hanke K, Faust K, Pagel J, Eyvazzadeh L, Brenner K, Roll C, Pirr S, Viemann D, Stavropoulou D, Henneke P, Tröger B, Körner T, Stein A, Derouet C, Zemlin M, Wieg C, Rupp J, Herting E, Göpel W, Härtel C.

Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics are beneficial to extremely low gestational age infants fed human milk.

Nutrients. 2020.12:850.

 

Humberg A, Härtel C, Rausch TK, Stichtenoth G, Jung P, Wieg C, Kribs A, von der Wense A, Weller U, Höhn T, Olbertz DM, Felderhoff-Müser U, Rossi R, Teig N, Heitmann F, Schmidtke S, Bohnhorst B, Vochem M, Segerer H, Möller J, Eichhorn JG, Wintgens J, Böttger R, Hubert M, Dördelmann M, Hillebrand G, Roll C, Jensen R, Zemlin M, Mögel M, Werner C, Schäfer S, Schaible T, Franz A, Heldmann M, Ehlers S, Kannt O, Orlikowsky T, Gerleve H, Schneider K, Haase R, Böckenholt K, Linnemann K, Herting E, Göpel W.

Active perinatal care of preterm infants in the German Neonatal Network.

Arch Dis Child Fetal Neonatal Ed. 2020. 105: 190-195.

 

Marissen J, Fortmann I, Humberg A, Rausch TK, Simon A, Stein A, Schaible T, Eichhorn J, Wintgens J, Roll C, Heitmann F, Herting E, Göpel W, Härtel C, German Neonatal Network.

Vancomycin-induced ototoxicity in very-low-birthweight infants.

J Antimicrob Chemother. 2020; doi: 10.1093/jac/dkaa156.

Humberg A, Fortmann I, Siller B, Kopp MV, Herting E, Göpel W, Härtel C, German Neonatal Network, German Center for Lung Research and Priming Immunity at the beginning of life (PRIMAL) Consortium.

Preterm birth and sustained inflammation: consequences for the neonate.

Semin Immunopathol. 2020; doi: 101007/s00281-020-00803-2

Astiz M, Heyde I, Fortmann MI, Bossung V, Roll C, Stein A, Grüttner B, Göpel W, Härtel C, Obleser J, Oster H.

The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders.

Nat Commun. 2020. 11:3593.

Kolter J, Kierdorf K, Henneke P.

Origin and Differentiation of Nerve-Associated Macrophages

J Immunol. 2020. 204(2):271-279.

Ammann S, Fuchs S, Martin-Martin L, Castro CN, Spielberger B, Klemann C, Elling R, Heeg M, Speckmann C, Hainmann I, Kaiser-Labusch P,  Horneff G, Thalhammer J, Bredius RG, Stadt UZ, Lehmberg K, Fuchs I, von Spee-Mayer C, Henneke P, Ehl S.

Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies

J Allergy Clin Immunol. 2020. 145(1):434-437.e4; doi: 10.1016/j.jaci.2019.09.002. 

Tröger B, Heidemann M, Osthues I, Knaack D, Göpel W, Herting E, Knobloch JK, Härtel C.

Modulation of S. epidermidis-induced innate immune responses in neonatal whole blood

J Microbiol Immunol Infect 2020. 53: 240-249

2019

Marißen J, Haiß A, Meyer C, Van Rossum T, Bünte LM, Frommhold D, Gille C, Goedicke-Fritz S, Göpel W, Hudalla H, Pagel J, Pirr S, Siller B, Viemann D, Vens M, König I, Herting E, Zemlin M, Gehring S, Bork P, Henneke P, Härtel C; PRIMAL consortium. 2019.

Efficacy of Bifidobacterium animalis subsp. lactis (BB-12), B. infantis and Lactobacillus acidophilus (La-5) probiotics to prevent gut dysbiosis in preterm infants of 28+0-32+6 weeks of gestation: a randomised, placebo-controlled, double-blind, multicentre trial: the PRIMAL Clinical Study protocol

BMJ Open. 9(11):e032617.

Feuerstein R, Gres V, Perdigo NE, Baasch S, Freudenhammer M, Elling R, Henneke P. 2019.

Macrophages are a potent source of streptococcus-induced interferon-β

J Immunol 19; published online 15 November 2019

Freudenhammer M, Henneke P, Härtel C. 2019.

Mikrobiom von Risikoneugeborenen und präventive Modifikation

Monatsschr Kinderh 19, 167:411–419

Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d’Errico P, Baasch S, Amann L, Masuda T, Lösslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke C, Grün D, Lämmermann T, Prinz M, Henneke P. 2019.

A subset of skin macrophages contributes to surveillance and regeneration of local nerves

Immunity 19; 50(6):1482-1497

Gres V, Kolter J, Erny D, Henneke P. 2019.

The role of CNS macrophages in streptococcal meningoencephalitis

J Leukoc Biol 19; 106(1):209-218

Twisselmann N, Bartsch YC, Pagel J, Wieg C, Hartz A, Ehlers M, Härtel C. 2019.

IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age

Front Immunol 19; 9:3166

2018

Fortmann I, Hartz A, Paul P, Pulzer F, Müller A, Böttger R, Proquitté H, Dawczynski K, Simon A, Rupp J, Herting E, Göpel W, Härtel C; German Neonatal Network. 2018.

Antifungal Treatment and Outcome in Very-Low-Birth-Weight-Infants – A Population-Based Observational Study of the German Neonatal Network

Pediatr Infect Dis J 18; 37: 1165-1171

Graspeuntner S, Waschina S, Künzel S, Twisselmann N, Rausch TK, Cloppenborg-Schmidt K, Zimmermann J, Viemann D, Herting E, Göpel W, Baines JF, Kaleta C, Rupp J, Härtel C, Pagel J. 2018.

Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants

Clin Infect Dis 18; 69(2):268-277

Härtel C, Paul P, Hanke K, Humberg A, Kribs A, Mehler K, Vochem M, Wieg C, Roll C, Herting E, Göpel W. 2018.

Less invasive surfactant administration and complications of preterm birt

Sci Rep 18; 8: 8333

Hartz A, Schreiter L, Pagel J, Moser K, Wieg C, Grotheer A, Rupp J, Herting E, Göpel W, Härtel C. 2018.

Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants

Pediatr Res 18; 84: 134-138

Hudalla H, Karenberg K, Kuon R, Pöschl J, Tschada R, Frommhold D. 2018.

LPS-induced maternal inflammation promotes fetal leukocyte recruitment and prenatal organ infiltration in mice

Pediatr Res 18; 84:757 – 764

Schwarz J, Scheckenbach V, Kugel H, Spring B, Pagel J, Härtel C, Pauluschke-Fröhlich J, Peter A, Poets CF, Gille C, Köstlin N. 2018.

Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period

Clin Exp Immunol 18; 191: 328-337

2017

Härtel C, Pagel J, Spiegler J, Buma J, Henneke P, Zemlin M, Viemann D, Gille C, Gehring S, Frommhold D, Rupp J, Herting E, Göpel W. 2017.

Lactobacillus acidophilus/ Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics

Sci Rep 17; 7:5633

Köstlin N, Vogelmann M, Spring B, Schwarz J, Feucht J, Härtel C, Orlikowsky TW, Poets CF, Gille C. 2017.

Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype

Immunology 17; 152: 89-101

Kolter J, Henneke P. 2017.

Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease

Font Immunol 17; 8:1497

Pirr S, Richter M, Fehlhaber B, Pagel J, Härtel C, Roth J, Vogl T, Viemann D. 2017.

High Amounts of S100-Alarmins Confer Antimicrobial Activity on Human Breast Milk Targeting Pathogens Relevant in Neonatal Sepsis

Front Immunol 17;  8: 1822

Veranstaltungen

13 – 14 July 2017

Kick-off meeting of the PRIMAL Consortium

Frankfurt, Germany

27 – 29 September 2017

Development of tissue and pathogen specific cellular innate immunity. International Symposium

Freiburg, Germany

28 February 2018

Workshop PRIMAL Biosamples and 2nd meeting of the PRIMAL Consortium

Hannover, Germany

20 September 2018

3rd meeting of the PRIMAL Consortium

Lübeck, Germany

3 – 4  April 2019

4th meeting of the PRIMAL Consortium

Freiburg, Germany

7 – 11 Juni 2020

Immunity in Early Life: From the Maternal to the Microbial Environment

Keystone Resort, Keystone, CO, USA

weitere Informationen:
http://bit.ly/KSimmune20

Media Toolkit:
http://bit.ly/DTKimmune20

2  Dezember 2020

5th meeting of the PRIMAL Consortium

web-meeting

1 – 2  Juli 2021

6th meeting of the PRIMAL Consortium

Würzburg, Germany